Celgene Principal Scientist, Translational Biology (Protein Homeostasis) in San Diego, California

Description

Celgene Research and Development

Celgene is a global biopharmaceutical company committed to innovation and the development of novel agents that will help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture. Research and Early Development at Celgene is organized into 4 key thematic centers, each focused to certain areas of biology. Within each these areas, discovery research, translational research, and early clinical development are integrated into a single team. These thematic centers comprise Protein Homeostasis; Epigenetics; Immuno-Oncology and Inflammation & Immunology.

Summary and Scope

The Celgene Protein Homeostasis Thematic Center is seeking a talented, experienced translational biologist with a track record in deriving valid biological insights from complex data. In particular with a strong focus on cancer disease mechanisms and the optimization of treatment benefit in a bedside-to-bench setting. This individual will play a key scientific role in planning analyses and deriving data from pre-clinical studies and clinical materials, and using these data to drive translational understanding and development of novel agents in Celgene’s Research and Early Development organization.

Experience evaluating and deploying technologies in genome, transcriptome, and proteome characterization to clinical samples and data, and demonstrated success in deriving novel biological information and insight into clinical outcomes from such data, is required.

The position will require an individual with exceptional scientific insight and excellent communication and collaboration skills. Applications are encouraged from those looking to bridge the capabilities and strengths of academic and industrial research environments to enable the development of truly innovative, life-changing therapies. As a member of an integrated discovery research and early development team, this role will also involve collaboration with discovery biology and chemistry researchers, clinicians, and computational biologists.

A keen interest in the emerging biology and therapeutic potential of regulated protein turnover and stability will be helpful. We are particularly interested to hear from individuals with deep knowledge and skills in genetic and protein interaction networks and pathway dependencies. In particular, a knowledge of pathways relevant to oncology would be helpful.

This position will report to a translational leader within the Protein Homeostasis Thematic center of Excellence, and will be located in San Diego, California. Exceptional candidates who are geographically constrained may also be considered.

Key Responsibilities

  • Key contributor to translational science in the context of early-phase clinical trials

  • Collaborate with discovery biologists, computational biologists, and clinicians to translate understanding of in vivo drug mechanisms and disease biology into efficient clinical trials

  • Define testable hypotheses and recommendations on dose and schedule, combinations, and subsets to optimize efficacy and patient outcomes

  • Design experiments to test hypotheses from clinical observations in preclinical model systems

  • Author and oversee writing of study reports, patents, assay protocols, and peer-reviewed publications. Presentation of methods, results and conclusions to publishable standards

  • Work across geographies and scientific domains

  • Analyze clinical and preclinical data to increase understanding of in vivo exposures, associated pathway modulations in different tissues and cells, and consequences for both efficacy and toxicity

  • Evaluate and advise on clinical trial biomarker/exploratory endpoint strategies, collect and analyze patient data to inform clinical development

  • Define data that will increase understanding of drug action and strategies to acquire it

  • Interact with project teams, academic collaborators and contract laboratories to design in vitro and in vivo studies to evaluate drug candidates

  • Manage relationships and critically review data from contract labs and academic collaborators

  • Present work at group meetings, internal forums and scientific conferences

  • Mentor research staff through instruction, coaching and guidance

Qualifications

Prerequisites

  • Ph.D. in Cell Biology, Molecular Biology, Biochemistry or a related scientific discipline with at least 8 years of pharmaceutical industry experience.

Required Skills and Knowledge

  • Strong base of biology and drug development knowledge and experience

  • Real-world clinical trial translational experience and understanding of key challenges and decisions in clinical development

  • Expert in the acquisition and interpretation of NGS, omic, and other analysis methods that generate high-dimensional data

  • Proven ability to derive novel insights from complex data

  • Ability to interpret and summarize scientific data in an accurate, critical and concise manner

  • Flexible and adaptable to changing priorities

  • Experienced in the integration of preclinical research through to clinical drug development

  • Highly effective teamwork and interpersonal skills

  • Exceptional written and verbal communications skills.

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

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BIO-US

Principal Scientist, Translational Biology (Protein Homeostasis)

Location: San Diego, CA, US

Job ID: 17001565