Celgene Assoc Scientist, Biology - Immunology& Inflammation in Cambridge, Massachusetts

Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Summary/Scope

The Immunology& Inflammation Late Discovery Biology group is seeking a self-motivated, energetic, detail-oriented candidate with strong background in cellular immunology and molecular biology. The primary focus of this position will be to develop and perform a variety of in vitro assays, with human or animal immune cells (primary or cell lines), to evaluate novel small molecules for drug candidate screening, lead optimization, and mechanism of action. The individual will participate in a broad range of programs in a dynamic, small research group and be comfortable working in a fast paced environment. Strong problem solving and time management skills are essential to complete diverse assigned tasks. The position requires excellent communication skills and an ability to present data, and the ability and willingness to work effectively in a highly collaborative research environment. Industry experience is preferred.

Responsibilities will include, but are not limited to, the following:

  • Design, plan, and execute cell based assays and troubleshoot existing protocols with guidance

  • Perform high quality and well controlled immunological assays with human and animal primary immune cells including cell stimulation, cytokine analysis, and flow cytometry with minimal supervision

  • Support scientists in execution of proof-of-concept studies.

  • Generate and independently analyze multi-parameters data sets using appropriate analytic programs

  • Maintain well written and accurate research electronic notebook detailing work undertaken

  • Comply with laboratory safety procedures

Skills/Knowledge Required:

  • Experience in isolation, culture, and characterization of primary immune cells from human and animal tissues

  • Hands-on experience with common immunological assays (cell activation, proliferation assays, cytokine analysis by FACS and ELISA, and multiplex assays)

  • Experience with lymphocyte and myeloid cell activation and characterization assays, multi-parameter flow cytometry, ELISA, ELISpot, RT-PCR, RNA preparation, viral transduction, mammalian cell transfection, immunoprecipitation, and western blotting.

  • Proficiency with FlowJo, Prism, and Microsoft office applications.

  • Possess a thorough knowledge of experimental design and underlying scientific principles

  • Team player, skills in liaising with other departments

  • Excellent organizational, record keeping, oral and written communication skills

Qualifications:

Bachelor’s degree in a scientific discipline with at least 6 years work experience or Master’s degree with at least 4 years work experience

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE

At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.

“At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.”

There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.