Celgene Associate Scientist, Chemistry in Cambridge, Massachusetts

Description

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Summary/Scope

Responsibilities will include, but are not limited to, the following: 1) carry out routine purification needs (via SFC and HPLC) for the medicinal chemistry team, 2) develop and optimize analytical methods, 3) synthesize and purify small focused libraries for medicinal chemistry projects, 4) compose reports and findings in descriptive and clear formats to the supervisor or chemistry colleagues.

This position is in the HTMC (High Throughput Medicinal Chemistry) group which is part of the medicinal chemistry group at Celgene Cambridge.

Responsibilities will include, but are not limited to, the following:

  1. Responsible for the routine purification needs for the medicinal chemistry team - Chiral purification using SFC, achiral purifications using HPLC

  2. Responsible for the routine method development and analysis of chiral and achiral compounds as well as interpreting data and communicating results to medicinal chemistry team members

  3. Maintain the high-throughput purification lab and associated equipment, including open access instrumentation and guiding others on the use of the instrumentations

  4. Under supervision, carry out synthesis and purification of project-specific small focused libraries

  5. Routine use of an electronic laboratory notebook (ELN)

  6. Presentations in departmental or project meetings, as needed

Qualifications

Bachelor’s degree in a chemistry or related scientific discipline with at least 6 years work experience or Master’s degree with at least 4 years work experience

Skills / Knowledge Required:

  • Experience with automated preparative HPLC systems

  • Experience and skills in LC method development

  • Basic organic synthesis skills / experience

  • Experience in preparing and purifying small parallel libraries preferred (but not required)

  • Understanding of medicinal chemistry principles and practices as it relates to analog / library design

  • Ability to work on multiple tasks / projects simultaneously

  • Good written and oral communication skills

  • Motivation to work in a fast paced, dynamic biotech environment

Other Characteristics & Traits:

• Demonstrate independent, scientifically-directed, and innovative thinking

• Anticipate the need for contingencies and develop alternative strategies

• Understanding of function as it relates to achievement of department or project needs and goals

• A good team player

#LI-POST

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE

At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.

“At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.”

There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.