Celgene Associate Scientist, Pharmacology (In-vivo) in Cambridge, Massachusetts
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
This candidate must be proficient in handling rodents (rats and mice) and able to calculate dose formulations, prepare formulations, administer compounds via various routes (IV, PO, IP), and collect blood and various tissue samples for analysis.Also, this candidate should be proficient in data collection/documentation, either in electronic or hardcopy forms.Pristima experience is preferred.
This individual is also expected to be highly organized, detail oriented, a team player, enthusiastic about drug discovery, and a strong communicator with a strong work ethic.
Responsibilities will include, but are not limited to, the following:
Design and conduct in vivo studies in rodents to establish PK/PD relationships, and in vivo proof of concept for target validation in a dynamic, fast-paced discovery environment. Directly enable the conduct of in vivo studies. Demonstrated expertise in small animal handling, dosing, recording of observations, blood and tissue collection and necropsy required. Ability to prepare dose formulations including calculation of dose amounts/volumes and the ability to prepare routine formulations. Data collection in electronic notebook or in hardcopy laboratory notebooks is critical. Communicate effectively within the Preclinical Sciences group, which includes colleagues in PK/bioanalysis.
Bachelor’s degree in biology, pharmacology/toxicology or related life science discipline with at least 6 years work experience or Master’s degree with at least 4 years work experience. Laboratory experience in small animal pharmacology model design/execution and solid understanding of in vivo pharmacology in a related discipline is required. Knowledge of rodent models of inflammation is preferred.
Experience in in vivo study conduct; animal handling, husbandry, dosing by multiple routes, observation recording, blood, tissue collection and limited necropsy.
Ability to generate protocols, and record data in a notebook (electronic or hardcopy)
Ability to generate high quality data in a dynamic high paced environment
Knowledge of rodent models of inflammation/immunology
Proficiency in Pristima
Strong presence as well as sense of urgency and priorities as well as flexibility. The ability and strong desire to "make things happen".
Decisive as well as collaborative.
High level of honesty and integrity.
Excellent interpersonal skills with particular emphasis on communication & relationship building.
Motivated to be part of an organization that aims to make a difference through cutting edge research.
Passion for the pharmaceutical industry.
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE
At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.
“At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.”
There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.