Celgene Scientist II, Pharmacology (Pre-Clinical/In-vivo) in Cambridge, Massachusetts
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
The Scientist II, Pharmacology will provide scientific support to the discovery organization by providing knowledge and experience in in vivo proof of principle support for small molecule target validation, specifically in the immunology/inflammation disease area. Experience in flow cytometry, as a component of the ex vivo analysis of rodent samples, is highly desired. The pharmacologist will participate at the discovery project team level, and will assure a quality product delivery for team decision making. This role includes both a bench presence and project team membership, and will require that the candidate can navigate both of these responsibilities.
Responsibilities will include, but are not limited to, the following:
Design and conduct in vivo studies in rodents to establish PK/PD relationships using acute local inflammation or other short-term endpoints, and in vivo proof of concept pharmacology for target validation in an immunology/inflammation-focused discovery environment. Knowledge of and direct experience with models of inflammatory disease (IBD, psoriasis, arthritis/spondylitis) and endpoints/drives of disease in rodent models. Experience in flow cytometry of samples collected from pharmacology studies, including analysis and interpretation for discovery teams. Timely and accurate data collection in electronic notebook or in hardcopy laboratory notebooks is critical. Participates as a member of discovery teams to provide knowledge from the pharmacology discipline. Communicate and collaborate effectively within group to establish clear priorities and seek alignment on a workplan that meets discovery team needs
PhD in Pharmacology, Animal Science, or a related biological discipline with at least 4 years relevant pharmaceutical R&D experience preferred. Bachelor’s degree in a scientific discipline with at least 12 years work experience or Master’s degree with at least 10 years work experience. Previous experience with design and execution of preclinical pharmacology studies, to support multiple indications in inflammatory diseases is required.
Solid understand of in vivo models of inflammatory disease, including ex vivo evaluations of small molecules targeted to immune/inflammatory disease targets.
Ability to generate high quality data in a dynamic high paced environment
Experience in flow cytometry execution and interpretation
Experience in in vivo study conduct; animal handling, dosing by multiple routes, observation recording, blood, tissue collection and limited necropsy.
Ability to generate protocols, and record data in a notebook (electronic or hardcopy)
• Knowledge of immunology/inflammation• Knowledge of in vitro assessment of pharmacologic activity
Strong presence as well as sense of urgency and priorities as well as flexibility. The ability and strong desire to "make things happen".
High level of honesty and integrity.
Excellent interpersonal skills with particular emphasis on communication & relationship building.
Motivated to be part of an organization that aims to make a difference through cutting edge research.
Passion for the pharmaceutical industry.
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE
At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.
“At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.”
There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.