Celgene Cheminformatics / Data Specialist in San Diego, California
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
As a member of the laboratory informatics group, the individual will be responsible for the strategic planning and creation of cheminformatics tools for compound management, data tracking, analysis, and visualization for Celgene research and early development (R&ED). The position is based in San Diego, CA, requires a highly motivated and skilled professional with extensive industry drug discovery expertise, experience contributing in a distributed research environment, and ability to partner with senior Research and IT leadership to develop and execute strategic plans for world-class data analytics capabilities.
This position would suit candidates with a synthetic chemistry background, familiar with the drug discovery process, looking to transition into a specialist role to facilitate data acquisition and data utilization for research and early development. .
Responsibilities will include, but are not limited to, the following:
Identify best practices and scientific applications, incorporating business needs and collaborating with IT in order to implement and execute plans across multiple sites within Celgene R&ED. This individual will also help to contribute ideas for compound and data management.
Serve as a scientific liaison with researchers in order to understand and interpret work flows and data processes. Design and implement solutions within scientific applications while working with the researchers on user requirements and desired functionality.
Translate scientific processes and solutions to IT personnel and/or vendors in order to enable, implement, and execute solutions within existing, under-development, or new IT infrastructure/initiatives.
Serve as a primary systems, application, and enhancements tester in order to deliver stable releases of applications to researchers.
Train IT personnel to enable adequate support to researchers on the use of various scientific applications.
Provide training to researchers on the use of scientific application on an as needed basis.
Contribute on various governance committees in order to ensure high data quality, standardization, harmonization, and compliance.
Evaluate new scientific applications and systems, as needed.
Develop, in collaboration with the screening, compound management, and informatics teams, operational strategies to ensure best practices necessary for high throughput screening, including but not limited to the acquisition, integration, and optimization of current or new instrumentation.
Provide design, programming, and troubleshooting support for automated laboratory robotics systems.
Produce high quality end user documentation and system/internal documentation.
Bachelor’s degree in Chemistry or related Scientific field with at least 12 years, Master’s degree with at least 10 years, or PhD with at least 5 years pharmaceutical industry/drug discovery experience.
Synthetic chemistry expertise, including synthetic contributions to small molecule drug discovery projects is required.
Extensive knowledge of medicinal chemistry work flows and processes including record keeping and data capture into electronic laboratory notebooks (ELN) and databases is required.
Bench-level experience with specialized chemistry instruments such as HPLC, GC/MS, LC/MS, NMR, etc. is highly desirable.
Hands-on experience using and programming various robotic systems such as but not limited to: TTPLabtech, Biosero, Tecan, Beckman, Hamilton, Perkin Elmer, pin tools, and acoustic dispensers is a plus. Experience using and programming at least one scientific application from the following is required: Activity Base, Sargen/Sarview, Dotmatics, Pipeline Pilot, Knime, Core Informatics, Labmatrix, Genedata, Spotfire, Electronic Laboratory Notebooks (ELN), XLFit, Prism, Seurat/LiveDesign, and R. Broad knowledge with databases (Oracle, SQL, Toad, etc.) and programming languages (perl, python, java, json, PL/SQL, VB.NET, VBA, etc.) is highly desired.
Extensive experience in a global research environment with an emphasis on laboratory automation, research informatics solutions-including LIMS, high throughput screening, and compound sample management is a plus.
Familiarity with the drug discovery process with an emphasis on compound management, analytical chemistry, high throughput medicinal chemistry, and data tracking and visualization.
Self-motivated with the ability to quickly learn, apply, and implement new software and technology.
Strong desire to learn new applications/processes and to become a primary point of contact to teach and support its use.
Ability to work independently and in a collaborative team-oriented setting. Demonstrate strong analytical, organizational, and communication skills.
The candidate should possess a previous background in providing strategic and scientific leadership for automation laboratory needs including:
Creating acceptance specifications and executing acceptance testing for automated laboratory solutions
Creating/configuring informatics tools to support laboratory operations
Translating laboratory methods into automated protocols
Integrating standard and custom hardware/software into laboratory automation systems
Developing novel storage solutions for samples
Laboratory design, renovation, relocation, instrumentation moves and operational assistance
Managing multiple, large and small scale automation projects
Flexibly adapting to changing business needs and priorities
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE
At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.
“At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.”
There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.