Celgene Sr. Scientist, Translational Biology in San Francisco, California


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Celgene Research and Development

Research and Early Development at Celgene is organized into 4 key thematic centers, each focused to certain areas of biology. Within each these areas, discovery research, translational research, and early clinical development are integrated into a single team. These thematic centers comprise Protein Homeostasis, Epigenetics, Immuno-Oncology, and Immunology and Inflammatory Disease.

Summary and Scope

The Celgene Protein Homeostasis Thematic Center is seeking a talented, experienced biologist with a track record of designing and executing laboratory and clinical research that yields translationally valid insights. The successful candidate will have a strong foundation in cancer disease mechanisms and a desire to inform development strategy and optimize treatment benefit, working with novel agents in an early development setting.

The position will require an individual with exceptional scientific insight and excellent communication and collaboration skills. Applications are encouraged from those looking to bridge the capabilities and strengths of academic and industrial research environments to enable the development of truly innovative, life-changing therapies. As a member of an integrated discovery research and early development team, this role will also involve collaboration with discovery biology and chemistry researchers, clinicians, and computational biologists.

A keen interest in the emerging biology and therapeutic potential of regulated protein turnover and stability will be helpful.

This position will report to a translational leader within the Protein Homeostasis Thematic center of Excellence, and will be located in San Francisco, California.

Key Responsibilities:

  • Key contributor to translational science in the context of early-phase clinical trials

  • Participate in clinical study teams and provide translational data and interpretation to guide study decisions.

  • Collaborate with discovery biologists, computational biologists, and clinicians to translate understanding of in vivo drug mechanisms and disease biology into efficient clinical trials

  • Define testable hypotheses and recommendations on dose and schedule, combinations, and subsets to optimize efficacy and patient outcomes

  • Design experiments to test hypotheses from clinical observations in preclinical model systems

  • Author and oversee writing of study reports, patents, assay protocols, and peer-reviewed publications. Presentation of methods, results and conclusions to publishable standards

  • Work across geographies and scientific domains

  • Analyze clinical and preclinical data to increase understanding of in vivo exposures, associated pathway modulations in different tissues and cells, and consequences for both efficacy and toxicity

  • Evaluate and advise on clinical trial biomarker/exploratory endpoint strategies, collect and analyze patient data to inform clinical development

  • Define data that will increase understanding of drug action and strategies to acquire it

  • Interact with project teams, academic collaborators and contract laboratories to design in vitro and in vivo studies to evaluate drug candidates

  • Manage relationships and critically review data from contract labs and academic collaborators

  • Present work at group meetings, internal forums and scientific conferences


Ph.D. in Cell Biology, Molecular Biology, Biochemistry or a related scientific discipline with at least 6 years of pharmaceutical industry experience.

Required Skills and Knowledge:

  • Strong base of biology and drug development knowledge and experience

  • Real-world clinical trial translational experience and understanding of key challenges and decisions in clinical development

  • A strong laboratory cell biology background and skillset, including omics and CRISPR methods, is essential.

  • Expert in the acquisition and (in collaboration with computational biologists) interpretation of NGS, proteomic, and other analysis methods that generate high-dimensional data

  • Ability to interpret and summarize scientific data in an accurate, critical and concise manner

  • Experience developing clinical-grade assays using flow cytometry, histology, ELISA, and DNA/ RNA methods is a plus.

  • Flexible and adaptable to changing priorities

  • Experienced in the integration of preclinical research through to clinical drug development

  • Highly effective teamwork and interpersonal skills

  • Exceptional written and verbal communications skills.



Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE

At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.

“At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.”

There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.